humorectomy
The surgical removal of a person's sense of humor. A common cure for a person who has had a humorectomy is a transfusion of teh lols.
Jim: I didn't find your joke funny at all. In fact, I thought it was offensive and vulgar, and I have half a mind to report you.
Bob: Looks like someone's had a humorectomy.
Bob: Looks like someone's had a humorectomy.