I don't know what I'm going to do with you!
Significant other is fed up or exhausted with the idea of you being around them.
Justin, you are getting to be too much and I'm confused about how I should handle you! You have made me mad/annoyed for the last time!!
("I don't know what I'm going to do with you!" is to be aggravated or annoyed by one's actions)
("I don't know what I'm going to do with you!" is to be aggravated or annoyed by one's actions)