It isn't what it isn't
Essentially the same meaning as "it is what it is", but to make it more clear that you can't "wish" for the unpleasant thing/situation/fate to not happen.
Dudebro 1: Dude my bank account just got hacked and I lost $2000, I wish this would've never happened to me.
Dudebro 2: It isn't what it isn't man.
Dudebro 2: It isn't what it isn't man.