Madden Factor
When winning in Madden in the 4th quarter, your team suddenly can't pass without throwing an INT or run without Fumbling, allowing your computer (or human) opponent to come back and win.
Going into the 4th quarter 2 minute warning I was up by 10 playing a great turnover-less game. Then I got Madden Factor'ed fumbled 3 times and lost by 7. What. The. Fuck.