Room rot
They are derived from staying in self-isolation in your room for too long. Common among gamers, who remain in their rooms for long periods of time without leaving to experience human contact. Therefore, they suffer from brain rot by being with themselves for so long.
"Have you seen Bill today?"
"Of course, not he's got room rot, haven't seen him for weeks."
"Of course, not he's got room rot, haven't seen him for weeks."