Saturos and Menardi
The two main antagonists in the game Golden Sun. Their goal in the game is to light all of the elemental lighthouses using the elemental stars, and release the power of alchemy upon the world of weyard. *spoilers* But eventualy, atop the venus lighthouse, they are stopped by Isaac and friends. After being bested by Isaac and friends, saturos throws the venus star into the lighthouse beacon, and it lights the lighthouse. Then, they pool their energy together and transform into the fusion dragon. Again, they are bested by Isaac and friends, and they both die. In the second game, saturos and menardi are considered protagonists because the main protagonist of the game, Felix, continues to light the remaining lighthouses.
Saturos and Menardi are the coolest video game villans ever.