Calm your hemorrhoids
A term used in response to someone who is overreacting. Similar to calm down, or relax.
#1: "WHY DO YOU KEEP ASKING ME IF I'M GOING TO TAKE OUT THE TRASH?!? I told you I'd do it!!!"
#2: "Dude, calm your hemorrhoids. I was just asking."
#2: "Dude, calm your hemorrhoids. I was just asking."