chlagonnaherpesyphilitisaids

(Pronounced like this: kla-GAH-nuh-HER-puh-SIH-fil-LIE-tus-AIDS)

In the literal sense, a combination of the best and brightest STDs: in order of appereance, chlamydia, gonorrhea, herpes, syphilis, hepatitis (insert letter here), and AIDS.

In the figurative sense, a really bad thing, a curse; usually used to blast some undesirable person to the depths or something like that.