Crossaligned
A state of either being positively of negatively overwhelmed by having taken two lines of two different drugs, too many times.
"Sorry I didn't make it to your birthday mate, I crossaligned after snorting too much ket and coke. Last thing I remember was that I was marrying an alpaca, but she was pretty cute. Then I killed her."
"Mate, you crossed a line."
"Mate, you crossed a line."