Darien Gap
The name of the boundary between Colombia and Panama and effectively North and South America. It is the most dangerous natural border in the world, with dense jungles, rugged terrain, and unpredictable flash floods being a big reason why there is still no road connecting the two continents. Crazier still, this continental barrier has existed since prehistoric times, having formed when North America became connected to South America via the Panama land bridge, allowing people and animals to migrate south. But despite the dangers anyone who attempts to cross from Colombia to Panama on foot will face, thousands of desperate migrants still risk their lives to make the treacherous crossing each year, hoping to eventually make it to the States.
The Darien Gap is behind only the Korean DMZ and the former Berlin Wall in terms of being the most dangerous borders in the world.